{"product_id":"abcam-ab249036","title":"Abcam, ab249036, Anti-ANKRD2 antibody [EPR10731(B)] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal ANKRD2 antibody. Carrier free. Suitable for ICC\/IF, WB and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR10731(B),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab249036 is the carrier-free version of\u003cbr\u003e\nab151718\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nANKRD2 also known as Arpp and MARP2 is an ankyrin repeat protein with a molecular mass of approximately 36 kDa. It is mainly expressed in skeletal muscle and cardiac muscle tissues. The protein functions by interacting with other proteins contributing to muscle structure and function. ANKRD2 binds to titin a critical sarcomeric protein playing a role in muscle elasticity and integrity.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nANKRD2 acts as a stretch sensor within muscle fibers. This role allows it to be part of a complex responsible for mediating mechanosignaling pathways that respond to mechanical stress or damage in muscle cells. ANKRD2 interacts with other signaling molecules like the transcription factor PML which modulates gene expression in response to mechanical cues.\u003cbr\u003e\nPathways\u003cbr\u003e\nANKRD2 participates in the muscle-specific mechanotransduction cascade. It plays a significant role in the modulation of MAPK signaling which is important for muscle growth and regeneration. The protein associates with other important proteins in this pathway such as titin and PML which work together to regulate muscle adaptation to physical stress.\u003cbr\u003e\nANKRD2 has an association with cardiomyopathy and muscular dystrophy. Its interactions with proteins such as titin and PML may influence the pathology of these diseases as these proteins are key in maintaining muscle and cardiac tissue stability. Disruption in ANKRD2 function or expression can contribute to muscular and cardiac impairments highlighting its importance in muscle-related conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850673967273,"sku":"ab249036","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab249036","provider":"Iright","version":"1.0","type":"link"}