{"product_id":"abcam-ab249141","title":"Abcam, ab249141, Anti-GBGT1 antibody [EPR10467] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal GBGT1 antibody. Carrier free. Suitable for IHC-P, WB, Flow Cyt (Intra) and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR10467,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:Flow Cyt (Intra), WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab249141 is the carrier-free version of\u003cbr\u003e\nab154837\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe GBGT1 protein also known as Forssman glycosyltransferase functions as an enzyme involved in the biosynthesis of the Forssman antigen. It is a glycosyltransferase enzyme that adds a specific sugar residue to the terminal position on glyco-conjugates. This enzyme typically weighs around 37 kDa. GBGT1 is expressed in a variety of tissues including the kidney heart and small intestine but its expression varies significantly among different species.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe Forssman glycosyltransferase enzyme is responsible for the generation of Forssman glycolipids contributing to the structure of cell membranes. These glycolipids play a role in cell-cell interactions. GBGT1 is not typically part of a larger protein complex but acts independently to modify glycolipids affecting cellular communication and recognition processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nGBGT1 is involved in glycosphingolipid biosynthesis pathways specifically influencing the metabolic progression from globoseries to Forssman series glycolipids. This pathway closely interacts with other enzymes like α13-galactosyltransferase which also contributes to glycolipid modification. These enzymes together maintain proper cellular roles involving signaling and interactions at the cell surface.\u003cbr\u003e\nGBGT1 engagement has been associated with immunological responses and cancer. Aberrant expression or mutation in this enzyme affects antigen presentation which contributes to various cancer types as the presence of Forssman antigen is often noted in tumor tissues. Furthermore it has connections with the α-galactosyltransferase enzyme in xenotransplantation as both are involved in the synthesis of glycolipids that can trigger immune rejection events.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851420618921,"sku":"ab249141","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab249141","provider":"Iright","version":"1.0","type":"link"}