{"product_id":"abcam-ab249165","title":"Abcam, ab249165, Anti-GNB3 antibody [EPR8862] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal GNB3 antibody. Carrier free. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR8862,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab249165 is the carrier-free version of\u003cbr\u003e\nab154866\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGNB3 also known as Guanine nucleotide-binding protein G(I)\/G(S)\/G(T) subunit beta-3 functions as an integral component of heterotrimeric G proteins. The protein has a mass of approximately 37 kDa. GNB3 is expressed in various tissues with significant expression in the brain and heart. It forms part of the G protein complex essential for transmitting signals from many hormones neurotransmitters and other signaling factors.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGNB3 interacts with alpha and gamma subunits to mediate signal transduction from G protein-coupled receptors (GPCRs). It plays a role in sensory perception neurotransmission and regulation of ion channels and certain enzymes. GNB3 is part of the G protein complex which appears critical in maintaining cellular response and adaptation to external signals. The interaction with different G protein subunits enables diverse regulatory effects on cellular functions.\u003cbr\u003e\nPathways\u003cbr\u003e\nGNB3 participates in the GPCR signaling pathway and the calcium signaling pathway. It interacts with G protein alpha subunits like GNAI1 and GNAS which are key players in these pathways. GPCR signaling affects numerous physiological processes involving aspects like cellular growth development and metabolic regulation. GNB3 contributes to converting the activated receptor signal into appropriate cellular responses.\u003cbr\u003e\nAltered GNB3 function associates with essential hypertension and obesity. Studies show connections between specific GNB3 polymorphisms and these conditions sometimes indicating variations in response to antihypertensive treatments. GNB3 interacts with components of the signal transduction pathways like the protein PLCB1 which may further elucidate its role in disease mechanisms. Understanding these interactions could enhance therapeutic strategies targeting related diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851788570793,"sku":"ab249165","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab249165","provider":"Iright","version":"1.0","type":"link"}