{"product_id":"abcam-ab249184","title":"Abcam, ab249184, Anti-FABP12 antibody [EPR10536] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal FABP12 antibody. Carrier free. Suitable for ICC\/IF, WB, Flow Cyt (Intra) and reacts with Human, Rat, Mouse samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR10536,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:Flow Cyt (Intra), WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab249184 is the carrier-free version of\u003cbr\u003e\nab155089\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nFABP12 also known as fatty acid-binding protein 12 plays a role in lipid transport and metabolism. This protein facilitates the binding and transport of long-chain fatty acids within cells. Although its exact molecular weight is not universally established similar fatty acid-binding proteins often have masses around 14-15 kDa. FABP12 expression primarily occurs in the mammalian retina with detectable levels in other tissues including certain types of cancer tissues.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nFABP12 influences cellular processes through its interaction with lipids. This protein contributes to fatty acid uptake and intracellular lipid homeostasis. It does not function as part of a larger macromolecular complex but interacts dynamically with fatty acids impacting lipid signaling and energy balance within the cell. Through these interactions FABP12 supports cellular energy production and lipid storage regulation.\u003cbr\u003e\nPathways\u003cbr\u003e\nFABP12 is involved in lipid metabolism and energy homeostasis pathways. One important pathway includes the peroxisome proliferator-activated receptor (PPAR) signaling pathway which regulates lipid metabolism. Nearby proteins like PPAR-alpha and PPAR-gamma are important for FABP12’s regulation of lipid-derived energy. Another relevant connection is to the retinoic acid signaling pathway where FABP12’s binding affinity with retinoids potentially influences cellular differentiation and development.\u003cbr\u003e\nResearch connects FABP12 to cancer and metabolic syndromes. In some cancers altered expression levels of FABP12 appear to influence tumor growth and metabolism. Studies have linked FABP12 with proteins such as FABP5 another member of the fatty acid-binding protein family in cancerous tissue dynamics. Additionally FABP12 involvement in metabolic disorders suggests a relationship with insulin resistance where its expression may impact the function of key proteins related to glucose metabolism.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851747250345,"sku":"ab249184","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab249184","provider":"Iright","version":"1.0","type":"link"}