{"product_id":"abcam-ab249222","title":"Abcam, ab249222, Anti-NOP58 antibody [EPR10721] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal NOP58 antibody. Carrier free. Suitable for IHC-P, ICC\/IF, WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR10721,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IHC-P, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab249222 is the carrier-free version of\u003cbr\u003e\nab155969\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nNOP58 also known as Nop58p is a nucleolar protein involved in the biogenesis of small nucleolar ribonucleoproteins (snoRNPs). This protein weighs approximately 58 kDa. Researchers find NOP58 expressed in the nucleolus of eukaryotic cells. NOP58 is part of the box C\/D small nucleolar RNA (snoRNA) complex which plays a critical role in the maturation and modification of pre-rRNA.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nNOP58 contributes to the assembly and function of snoRNPs which guide the chemical modification of rRNA particularly 2'-O-methylation. This modification has significance for proper ribosome assembly and function. NOP58 does not work alone; it forms part of a complex with other proteins such as NOP56 Fibrillarin and SNU13. These proteins come together to accurately target and chemically modify specific rRNA sequences.\u003cbr\u003e\nPathways\u003cbr\u003e\nNOP58 participates in the ribosome biogenesis and rRNA processing pathways. These pathways are essential for producing the ribosomal units required for protein synthesis. NOP58 functions alongside proteins like NOP56 and Fibrillarin in modifying rRNA which is critical within the nucleolus. Proper functioning of these pathways ensures the cell maintains protein synthesis efficiency and accuracy.\u003cbr\u003e\nAlterations in NOP58 may affect nucleolar function potentially leading to ribosomopathies. Disruptions in NOP58 can potentially associate with conditions such as cancer where nucleolar activity is often altered. Proteins like Fibrillarin associated with snoRNP complexes may also be implicated in these diseases as they share involvement in similar pathways and complex functions with NOP58.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851816358057,"sku":"ab249222","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab249222","provider":"Iright","version":"1.0","type":"link"}