{"product_id":"abcam-ab249303","title":"Abcam, ab249303, Anti-UPB1 antibody [EPR9132] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal UPB1 antibody. Carrier free. Suitable for IHC-P, IP, WB and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR9132,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IP, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab249303 is the carrier-free version of\u003cbr\u003e\nab157195\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nUPB1 also known as Ureidopropionase beta is an enzyme encoded by the UPB1 gene. It is approximately 37 kDa in mass. UPB1 conducts the hydrolysis of N-carbamoyl-beta-alanine and N-carbamoyl-beta-aminoisobutyric acid to provide beta-alanine beta-aminoisobutyric acid ammonia and carbon dioxide. It is commonly expressed in liver and kidney tissues.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nUPB1 plays an important role in the catabolic pathway of pyrimidine metabolism. This enzyme participates in the breakdown of uracil which is part of nucleotide catabolism. UPB1 operates independently rather than as a part of a protein complex. It ensures detoxification and recycling of nitrogenous compounds derived from pyrimidine breakdown.\u003cbr\u003e\nPathways\u003cbr\u003e\nUPB1 is an integral component of the pyrimidine metabolic pathway. It provides a link between the pyrimidine degradation pathway and general nitrogen metabolism by supplying beta-alanine. This function complements the enzymatic roles of dihydropyrimidine dehydrogenase (DPYD) and dihydropyrimidinase (DPYS) which are involved in earlier steps in the same degradation pathway.\u003cbr\u003e\nDisturbances associated with UPB1 can lead to a condition called N-carbamoyl-beta-amino aciduria. This is a metabolic disorder characterized by excessive accumulation of N-carbamoyl-beta-amino acids in urine. The interaction with proteins such as DPYS and DPYD may exacerbate or modify the severity of this metabolic condition as they are upstream components in the pyrimidine degradation pathway.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851811475625,"sku":"ab249303","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab249303","provider":"Iright","version":"1.0","type":"link"}