{"product_id":"abcam-ab249336","title":"Abcam, ab249336, Anti-UGPase antibody [EPR10626] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal UGPase antibody. Carrier free. Suitable for IHC-P, ICC\/IF, WB, Flow Cyt (Intra) and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR10626,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, ICC\/IF, WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab249336 is the carrier-free version of\u003cbr\u003e\nab157473\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nUGPase also known as UDP-glucose pyrophosphorylase plays an important role in carbohydrate metabolism by catalyzing the reversible formation of UDP-glucose and pyrophosphate from glucose-1-phosphate and UTP. The enzyme has a mass of about 52 kDa. UGPase is expressed in many tissues but especially in liver muscle and brain where carbohydrate metabolism is highly active. Its presence ensures the availability of UDP-glucose which serves as a glycosyl donor in the synthesis of glycogen.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nUGPase provides UDP-glucose a central metabolite in carbohydrate biosynthesis. It does not function as part of a complex but independently supports various biosynthetic pathways. UDP-glucose acts as a precursor not only for glycogen but also for glycoproteins glycolipids and proteoglycans. UGPase activity is critical for maintaining glucose homeostasis and its regulation directly affects carbohydrate allocation and storage.\u003cbr\u003e\nPathways\u003cbr\u003e\nUGPase operates in the glycogen synthesis pathway and the pentose phosphate pathway. In the glycogen synthesis pathway UGPase works closely with glycogen synthase which converts UDP-glucose into glycogen helping in energy storage. In the pentose phosphate pathway UDP-glucose serves as a substrate for enzymes modifying carbohydrate structures. These pathway interactions place UGPase as an essential node linking carbohydrate metabolism routes.\u003cbr\u003e\nThe dysregulation of UGPase affects disorders like glycogen storage diseases and diabetes. An abnormal UGPase activity can lead to inefficient glycogen storage impacting energy balance and contributing to these conditions. The enzyme also connects with proteins like glycogen synthase in glycogen storage diseases illustrating how alterations in its function can disturb glycogen synthesis and storage. Understanding UGPase activity therefore offers insights into metabolic imbalances seen in these diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46860389974185,"sku":"ab249336","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab249336","provider":"Iright","version":"1.0","type":"link"}