{"product_id":"abcam-ab249415","title":"Abcam, ab249415, Anti-PSMG1 antibody [EPR10223] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal PSMG1 antibody. Carrier free. Suitable for IHC-P, ICC\/IF, IP, WB and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR10223,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WB, IP, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab249415 is the carrier-free version of\u003cbr\u003e\nab167396\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPSMG1 also known as Proteasome Assembly Chaperone 1 or PAC1 is involved in the assembly of the 20S proteasome complex which is essential for protein degradation. This protein has a mass of approximately 36 kDa. Researchers have identified its expression primarily in the cytoplasm and nucleus of various cell types across different human tissues suggesting a broad functional role.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPSMG1 participates as a chaperone that guides the proper assembly of the proteasome complex. It partners with other chaperones such as PSMG2 to help ensure that the proteasome particles achieve their correct configuration. By doing so it maintains protein homeostasis within cells which is essential for cellular function and survival. Its activity is critical for regulating the protein quality control system.\u003cbr\u003e\nPathways\u003cbr\u003e\nPSMG1 plays a role in the ubiquitin-proteasome pathway which is responsible for protein degradation and turnover. This protein also interacts with other components of the pathway such as ubiquitin and various proteasome subunits. PSMG1's function within these pathways highlights its interaction with proteins involved in regulating the cell cycle and apoptosis ensuring cells respond properly to stress and damage.\u003cbr\u003e\nPSMG1 has been linked to conditions such as cancer and neurodegenerative diseases. Abnormalities in its function can lead to disruptions in the proteasome pathway affecting proteins like p53 an important regulator of cell cycle and apoptosis. These links point to the importance of PSMG1 in maintaining cellular integrity and underline its significance in disease progression offering potential insights for therapeutic targets.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851573416105,"sku":"ab249415","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab249415","provider":"Iright","version":"1.0","type":"link"}