{"product_id":"abcam-ab249519","title":"Abcam, ab249519, Anti-SPANXD antibody [EPR8902] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal SPANXD antibody. Carrier free. Suitable for WB and reacts with Mouse samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR8902,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab249519 is the carrier-free version of\u003cbr\u003e\nab169773\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nRat: We have preliminary internal testing data to indicate this antibody may not react with this species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSPANXD also known as Sperm Protein Associated with the Nucleus on the X Chromosome Family Member D is a protein with a molecular weight of approximately 11 kDa. SPANXD shows expression mainly in the testis and has a specific role during spermatogenesis. This protein belongs to the SPANX gene family which is particularly known for its expression in male germ cells. Additionally SPANXD appears to localize in the nucleus where it may play a role in chromatin organization during sperm development.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSPANXD functions in facilitating the proper packaging and organization of sperm chromatin ensuring genomic integrity during reproduction. It likely contributes to the final stages of sperm maturation particularly affecting chromatin condensation through interaction with the nuclear matrix. Although not extensively reported as part of large protein complexes SPANXD may work in conjunction with other SPANX family members to achieve its functional roles during sperm cell development.\u003cbr\u003e\nPathways\u003cbr\u003e\nSPANXD plays a part in the reproductive cellular pathways by ensuring the integrity and proper compaction of DNA in sperm cells. It is involved in spermatogenesis where it helps regulate the chromatin condensation process critical for functional sperm cells. Related proteins involved in these pathways include other family members like SPANXA and SPANXB which together may facilitate coordinated events during sperm cell development.\u003cbr\u003e\nResearchers link SPANXD to fertility issues particularly male infertility due to its sperm-specific expression and function. Abnormal SPANXD expression or dysfunction can result in improper sperm development. Its connection to SPANX family members suggests combined impacts on spermatogenesis where disruptions can lead to azoospermia or oligospermia. Understanding SPANXD's role could contribute to developing targeted treatments for these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852284416169,"sku":"ab249519","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab249519","provider":"Iright","version":"1.0","type":"link"}