{"product_id":"abcam-ab249596","title":"Abcam, ab249596, Anti-ZAN antibody [EPR11209] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal ZAN antibody. Carrier free. Suitable for WB and reacts with Mouse samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR11209,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab249596 is the carrier-free version of\u003cbr\u003e\nab170925\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nZAN also known as Zonadhesin is a sperm-specific protein involved in the binding of sperm to the egg's zona pellucida. It has a molecular mass of approximately 280 kDa. Zonadhesin's expression is primarily detected in the testis particularly in spermatogenic cells. This protein plays an essential role during fertilization by mediating the initial adherence of sperm to the egg surface which is an important step in the fertilization process.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis protein enables the gamete interaction necessary for successful reproduction. Zonadhesin functions by recognizing and binding to specific glycoproteins on the egg's zona pellucida. This interaction facilitates the penetration process allowing the sperm to deliver its genetic material into the egg. Zonadhesin operates alone and doesn’t join any known protein complex highlighting its autonomous action in gamete recognition.\u003cbr\u003e\nPathways\u003cbr\u003e\nZonadhesin's role in sperm-egg recognition directly implicates it in reproductive pathways particularly the acrosome reaction pathway which prepares the sperm for binding and penetrating the egg. It works in conjunction with acrosomal enzymes like acrosin which further facilitate the penetration of the zona pellucida. Zonadhesin's function in this pathway ensures that the sperm can navigate the zona pellucida barrier and engage in fertilization.\u003cbr\u003e\nAbnormalities in Zonadhesin expression or function may lead to fertility issues such as sperm incapacitation or male infertility. Dysfunction in this protein can disrupt sperm-zona pellucida interaction making successful fertilization challenging. In cases of infertility related to Zonadhesin there may be interest in the protein sperm antigen 17 (SP17) as it also plays a part in reproductive processes and imbalances or dysfunctions in either protein can contribute to reproductive disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852525654185,"sku":"ab249596","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab249596","provider":"Iright","version":"1.0","type":"link"}