{"product_id":"abcam-ab249638","title":"Abcam, ab249638, Anti-PDZRN4 antibody [EPR11852] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal PDZRN4 antibody. Carrier free. Suitable for IHC-P, WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR11852,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab249638 is the carrier-free version of\u003cbr\u003e\nab171083\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPDZRN4 also known as LNX4 (Ligand of Numb-Protein X 4) functions mechanically as a modular scaffold protein playing a role in protein-protein interactions. It belongs to the PDZ and RING finger protein family and contains both PDZ domains and a RING finger motif. PDZRN4 has a molecular mass of approximately 82 kDa. Researchers have found this protein highly expressed in regions of the central nervous system and testis suggesting tissue-specific roles and significance.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPDZRN4 facilitates interactions in cellular signaling networks. It acts as an important adaptor molecule that helps in organizing signaling complexes. PDZRN4 is often part of larger protein complexes integrating signals for proper neuronal development and function. It modulates synaptic transmission by interacting with other PDZ domain-containing proteins influencing receptor localization and synaptic stability.\u003cbr\u003e\nPathways\u003cbr\u003e\nPDZRN4 involves itself in synaptic signaling particularly impacting pathways related to neuronal communication and calcium signaling. It is most importantly connected to the Ras signaling pathway. PDZRN4 interacts with proteins like Numb which plays a part in cell fate determination and PSD-95 known for its role in synapse formation and stabilization. These interactions highlight its influence on neuronal plasticity and developmental processes.\u003cbr\u003e\nPDZRN4 has associations with neurological conditions specifically Alzheimer’s disease and autism spectrum disorders. Abnormal expression or dysfunction of PDZRN4 can disrupt synaptic architecture implicating it in cognitive impairments observed in Alzheimer's disease. The protein also interacts with Numb a significant player in the Notch signaling pathway contributing to neurodevelopmental disorders like autism when misregulated. These connections highlight PDZRN4's potential as a therapeutic target in managing these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851814031529,"sku":"ab249638","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab249638","provider":"Iright","version":"1.0","type":"link"}