{"product_id":"abcam-ab249768","title":"Abcam, ab249768, Anti-ADHFE1 antibody [EPR12501] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal ADHFE1 antibody. Carrier free. Suitable for IP, WB and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR12501,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab249768 is the carrier-free version of\u003cbr\u003e\nab173530\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nADHFE1 also known as alcohol dehydrogenase iron-containing 1 is a mitochondrial protein with a molecular mass of approximately 62 kDa. It is expressed in various tissues with higher levels in the liver kidney and heart. Functioning as a member of the iron-containing alcohol dehydrogenase family ADHFE1 catalyzes the conversion of alcohols into aldehydes an essential step in the metabolic pathway involving alcohols.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe enzyme facilitates important redox reactions that contribute to various metabolic processes. ADHFE1 is not part of a larger complex but acts independently in its role of oxidizing alcohols to aldehydes. It impacts metabolic regulation by modulating the levels of substrates and products involved in energy production and detoxification which is significant for maintaining cellular homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nADHFE1 plays an important role in the metabolic network of energy conversion and alcohol detoxification. It is integrated into the glycolytic pathway and interacts with other proteins like G6PD and LDHA which function in glucose metabolism and lactate production respectively. These interactions support cellular energy production and manage the fate of glucose-derived metabolites.\u003cbr\u003e\nADHFE1 involvement relates to metabolic disorders such as alcohol dependence and non-alcoholic fatty liver disease (NAFLD). In alcohol dependence ADHFE1's activity influences the concentration of acetaldehyde which may contribute to the disease's pathology. Additionally its expression and interaction with proteins like ADH1C and ALDH2 are relevant in the context of liver diseases impacting the metabolic balance and detoxification processes in the liver.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851918626985,"sku":"ab249768","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab249768","provider":"Iright","version":"1.0","type":"link"}