{"product_id":"abcam-ab249786","title":"Abcam, ab249786, Anti-GALNTL2 antibody [EPR11580] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal GALNTL2 antibody. Carrier free. Suitable for IHC-P, WB and reacts with Human, Mouse, Rat samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR11580,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab249786 is the carrier-free version of\u003cbr\u003e\nab174275\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGALNTL2 also known as Polypeptide N-Acetylgalactosaminyltransferase-like 2 is an enzyme that belongs to the polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family. This enzyme has a molecular mass of approximately 63 kDa. It plays an important mechanical role in the initiation of mucin-type O-glycosylation by transferring N-acetylgalactosamine to the hydroxyl group of serine or threonine residues on target proteins. These modifications are essential for protein function. GALNTL2 is widely expressed in different human tissues including the liver brain and heart indicating its involvement in various physiological processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe enzyme acts by modifying proteins to mediate their stability signaling and interaction with other molecules. GALNTL2 functions within a complex network of enzymes that manage glycosylation processes contributing to the modification of a variety of substrates. By altering protein structures through glycosylation it affects cell signaling pathways and immune responses. The enzyme's ability to modulate proteins influences processes like cellular adhesion and communication which are essential for maintaining tissue integrity and function.\u003cbr\u003e\nPathways\u003cbr\u003e\nGALNTL2 plays a role in the O-glycosylation pathway which is important for proper protein folding and function. This pathway intersects with the protein processing pathway in the endoplasmic reticulum. GALNTL2 acts in conjunction with other members of the GalNAc-T family including GALNT1 and GALNT2 to fine-tune the glycosylation of proteins that pass through the secretory pathway. These processes are important for orchestrating responses to cellular stress and maintaining cellular homeostasis.\u003cbr\u003e\nGALNTL2's dysfunction can relate to certain cancers and metabolic disorders. Abnormal glycosylation patterns due to mutations or misregulations in GALNTL2 have associations with cancer progression particularly in pathways involving cell-cell communication and adhesion influencing tumor growth and metastasis. Additionally metabolic disorders such as diabetes might also involve GALNTL2 through its interactions with signaling molecules like insulin. These associations highlight the importance of studying GALNTL2 for therapeutic targets in disease treatment.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46856367440041,"sku":"ab249786","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab249786","provider":"Iright","version":"1.0","type":"link"}