{"product_id":"abcam-ab250169","title":"Abcam, ab250169, Anti-MRPL4 antibody [EPR13151] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal MRPL4 antibody. Carrier free. Suitable for IHC-P, WB and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR13151,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab250169 is the carrier-free version of\u003cbr\u003e\nab180165\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMRPL4 also known as 39S ribosomal protein L4 mitochondrial is a mitochondrial ribosomal protein. This protein is a component of the large 39S subunit of the mitochondrial ribosome and has a molecular mass of approximately 39 kDa. MRPL4 is primarily expressed in tissues with high energy demands including the heart and skeletal muscle. It plays a role in mitochondrial protein synthesis facilitating the translation of proteins encoded by mitochondrial DNA.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMRPL4 assists in the assembly and stability of the mitochondrial ribosome forming part of the mitoribosome complex. This complex is essential for the synthesis of mitochondrial proteins which are critical for proper mitochondrial function. MRPL4 ensures accurate translation by binding to ribosomal RNA stabilizing the structure needed for efficient ribosomal activity. Its function is important for maintaining cellular energy production cellular growth and metabolism.\u003cbr\u003e\nPathways\u003cbr\u003e\nMRPL4 participates significantly in the mitochondrial translation pathway. This pathway is integral to the oxidative phosphorylation process which is essential for ATP production in cells. MRPL4 interacts with other ribosomal proteins such as MRPL3 and MRPL12 facilitating the coordination of protein synthesis within the mitochondrion. This process influences cellular respiration and bioenergetics which are critical for adapting to energy requirements.\u003cbr\u003e\nMRPL4 is associated with conditions like mitochondrial disorders and cardiac diseases. Alterations in MRPL4 expression or function can disrupt mitochondrial protein synthesis leading to impaired oxidative phosphorylation and energy production. Such mitochondrial dysfunction is linked to disorders like mitochondrial encephalomyopathy and cardiomyopathy. MRPL4's interactions with other ribosomal proteins ensure that changes in its structure or expression could influence disease progression making it a target for further research in mitochondrial medicine.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851142942889,"sku":"ab250169","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab250169","provider":"Iright","version":"1.0","type":"link"}