{"product_id":"abcam-ab250362","title":"Abcam, ab250362, Anti-RPUSD3 antibody [EPR12911] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal RPUSD3 antibody. Carrier free. Suitable for ICC\/IF, WB, Flow Cyt (Intra) and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR12911,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab250362 is the carrier-free version of\u003cbr\u003e\nab181121\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nRPUSD3 also known as RNA pseudouridylate synthase domain containing 3 is an enzyme involved in RNA modification. This protein has a mass of approximately 60 kDa and exhibits expression in various tissues including the brain heart and skeletal muscle. The enzyme plays a role in catalyzing the isomerization of uridine to pseudouridine in RNA molecules an important step for RNA stability and function.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nRPUSD3 contributes to the modification of ribosomal RNA (rRNA) enhancing its structural stability and translation fidelity. This protein operates as part of a ribonucleoprotein complex engaging with other molecules to facilitate the precise modification processes necessary for proper RNA function. These modifications are important for cellular health and protein biosynthesis.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe enzymatic activity of RPUSD3 integrates into the RNA modification pathway influencing an important process for gene expression regulation. It works alongside proteins like dyskerin which also participates in pseudouridine synthesis within the small subunit processome. This involvement positions RPUSD3 as a significant player in rRNA processing ensuring the correct assembly of ribosomes.\u003cbr\u003e\nAlterations in RPUSD3 activity have been connected to certain neurodevelopmental disorders. Research suggests that abnormal RPUSD3 function may contribute to intellectual disability where it is seen to interact with proteins involved in neuronal development such as FMRP. Additionally this protein's altered activity associates with metabolic disorders which highlights its relevance to maintaining normal metabolic processes.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851843424425,"sku":"ab250362","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab250362","provider":"Iright","version":"1.0","type":"link"}