{"product_id":"abcam-ab250514","title":"Abcam, ab250514, Anti-HABP2 antibody [EPR14551] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal HABP2 antibody. Carrier free. Suitable for ICC\/IF, WB, Flow Cyt (Intra) and reacts with Human, Mouse, Rat samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR14551,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:Flow Cyt (Intra), ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab250514 is the carrier-free version of\u003cbr\u003e\nab181837\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe Hyaluronan-Binding Protein 2 (HABP2) also known as Factor VII activating protease is a serine protease with an approximate mass of 65 kDa. This protein gets expressed mainly in the liver and secreted into the bloodstream. HABP2 participates in extracellular matrix interactions by binding to hyaluronan. It plays a role in coagulation processes. The protein also influences angiogenesis highlighting its mechanical involvement in vascular biology.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nHABP2 functions as a regulator in the maintenance of blood homeostasis and tissue remodeling. It takes part in fibrinolysis the process that prevents blood clots from growing and becoming problematic. HABP2 works together with fibrin to facilitate clot breakdown. It may also interact with plasminogen activators within these complexes to accomplish its biological functions effectively.\u003cbr\u003e\nPathways\u003cbr\u003e\nHABP2 integrates into the fibrinolytic and coagulation pathways. It contributes to ensuring that the balance between clot formation and breakdown is maintained. The protein shows interactions with other components like urokinase-type plasminogen activator (uPA) which also plays a role in fibrinolysis. This highlights HABP2's participation in processes that involve preventing thrombosis.\u003cbr\u003e\nHABP2 has associations with cardiovascular disorders including venous thromboembolism. Aberrant activity of HABP2 may contribute to an increased risk of thrombosis. The protein's interaction with plasminogen and fibrin suggests its involvement in abnormal clotting disorders. Further study into HABP2's role could aid in understanding its potential as a therapeutic target in these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851266379945,"sku":"ab250514","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab250514","provider":"Iright","version":"1.0","type":"link"}