{"product_id":"abcam-ab250640","title":"Abcam, ab250640, Anti-LLGL1 + LLGL2 antibody [EPR18899] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal LLGL1 antibody. Carrier free. Suitable for IP, WB, ICC\/IF, IHC-P and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR18899,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WB, IP, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:The immunogen used for this product shares 53% identity (67% positives) with LLGL2. Cross-reactivity with this protein has not been confirmed experimentally.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab250640 is the carrier-free version of\u003cbr\u003e\nab183021\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe LLGL1 and LLGL2 proteins also known as Lethal (2) giant larvae proteins play important roles in cell polarity and asymmetric cell division. LLGL1 has a molecular mass of approximately 130 kDa and is expressed in various tissues with notable presence in the brain and reproductive organs. LLGL2 shares similar distribution and expression patterns. These proteins structurally contain several WD40 repeats involved in protein-protein interactions that help them in functioning as cortical factors.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nIn epithelial cells and neural progenitors LLGL1 and LLGL2 are essential for maintaining cell polarity contributing to the structural stability and function of tissues. Both proteins are part of the Scribble complex a multi-protein assembly that regulates cell polarity and adhesion. By ensuring proper orientation and polarization of cells they are involved in tissue homeostasis and developmental processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nCell polarity and division control involves the LLGL1 and LLGL2 proteins. They are key components of the PAR (Partitioning-defective) pathway interplaying with proteins like aPKC and PAR-6 essential for spatial cellular orientation. Additionally they play a role in the Hippo signaling pathway which is important for organ size regulation and cell proliferation working alongside proteins such as YAP\/TAZ.\u003cbr\u003e\nDysfunction or alterations in LLGL1 and LLGL2 proteins have associations with cancer and neurological disorders. Loss of function can contribute to tumorigenesis highlighting their role as tumor suppressors in various cancer studies. In the context of neurological disorders improper regulation linked with these proteins can provide insight into brain development diseases interacting with proteins like Scribble and DLG variants.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851018752169,"sku":"ab250640","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab250640","provider":"Iright","version":"1.0","type":"link"}