{"product_id":"abcam-ab250651","title":"Abcam, ab250651, Anti-MK-3 antibody [EPR13969] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal MK-3 antibody. Carrier free. Suitable for IP, WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR13969,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IP, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab250651 is the carrier-free version of\u003cbr\u003e\nab183040\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMK-3 also known as MAP kinase-activated protein kinase 3 is a serine\/threonine kinase with a mass of approximately 43 kDa. It is widely expressed across various tissues including the brain heart and skeletal muscle. Mechanically MK-3 transduces signals from activated MAP kinases and phosphorylates downstream targets influencing their function and stability. This activity is central to many cellular processes particularly those related to responses to external stimuli.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMK-3 functions as part of the MAPK signaling cascade and phospho-regulates different substrates that influence cell differentiation and stress responses. The protein interacts within complexes that mediate cellular responses to growth factors and various extracellular signals. MK-3's enzymatic activity modulates pathways involved in inflammation and apoptosis which are essential for maintaining cellular homeostasis and responding to stress.\u003cbr\u003e\nPathways\u003cbr\u003e\nMK-3 plays a significant role in the MAPK and SAPK\/JNK pathways. These pathways help regulate responses to environmental stressors and cytokine signaling. MK-3 is closely related to other kinases like p38 MAPK and JNK which collaboratively modulate cellular stress responses. These pathways are important for facilitating communication between extracellular stimuli and intracellular actions.\u003cbr\u003e\nMK-3 has connections to inflammatory conditions and cancer. Inflammatory diseases such as rheumatoid arthritis involve altered MAPK signaling where MK-3 interacts with proteins such as cytokines that promote inflammation. In cancer aberrant MK-3 activity can support tumor progression by affecting apoptosis and cell cycle regulation linking to proteins like p53 that control cell division and death.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851890217129,"sku":"ab250651","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab250651","provider":"Iright","version":"1.0","type":"link"}