{"product_id":"abcam-ab250757","title":"Abcam, ab250757, Anti-SDS3 antibody [EPR15000] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal SDS3 antibody. Carrier free. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR15000,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab250757 is the carrier-free version of\u003cbr\u003e\nab184555\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSDS3 also known as SAP30 binding protein (SAP30BP) is a protein with a molecular weight of about 46 kDa. This protein is expressed in various tissues notably in the nucleus of cells. Mechanically SDS3 functions as a transcriptional regulator playing an essential role in chromatin remodeling and gene expression. It is a part of histone deacetylase complexes where it helps modulate the structural conformation of chromatin affecting DNA accessibility.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSDS3 exerts important roles by being a component of the Sin3a corepressor complex. This complex is responsible for the repression of transcription through histone modification specifically deacetylation which leads to chromatin condensation. In this way SDS3 contributes to silencing specific genes which can influence cell differentiation and proliferation. Its interactions within the complex contribute to the regulation of diverse genes vital for cellular homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nSDS3's interactions intervene in the transcriptional repression pathways and cell cycle regulation pathways. Involvement in these pathways showcases its role in maintaining proper cell division and controlling gene expression timing. SDS3 is closely related to other proteins like histone deacetylases HDAC1 and HDAC2 which participate in deacetylation activities that repress transcription and modify chromatin structure to restrict gene accessibility.\u003cbr\u003e\nSDS3 has been linked to various cancers due to its role in regulating genes that control cell proliferation and survival. Abnormal expression or function of SDS3 can lead to inappropriate transcriptional repression of tumor suppressor genes contributing to unchecked cell growth. Additionally SDS3 is associated with neurodegenerative disorders due to its role in gene expression regulation in neural cells. In these conditions SDS3 may interact with other proteins such as SIN3A and RBBP4 further impacting gene expression profiles.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851911352489,"sku":"ab250757","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab250757","provider":"Iright","version":"1.0","type":"link"}