{"product_id":"abcam-ab250785","title":"Abcam, ab250785, Anti-hnRNP Q antibody [EPR15096] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal hnRNP Q antibody. Carrier free. Suitable for IHC-P, ICC\/IF, WB and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR15096,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab250785 is the carrier-free version of\u003cbr\u003e\nab184946\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) also known as SYNCRIP or NSAP1 plays an important mechanical role in RNA metabolism. This protein has a mass of approximately 65 kDa and is expressed in a wide range of tissues with significant presence in the cytoplasm and nucleoplasm. hnRNP Q binds to RNA and participates in processes like mRNA splicing transport stabilization and translation regulation. It interacts with distinct RNA sequences influencing gene expression patterns important for cellular function.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nHnRNP Q is involved in various cellular processes and contributes to the post-transcriptional regulation of mRNA. It often forms part of ribonucleoprotein complexes where it modifies RNA molecule processing and stability. This interaction ensures proper translation and adaptation to the cell's needs. hnRNP Q's action is essential for neuronal development and synaptic plasticity highlighting its functional importance in the nervous system.\u003cbr\u003e\nPathways\u003cbr\u003e\nHnRNP Q engages in targeted pathways to influence cellular signaling and gene expression. It plays a role in the mTOR signaling pathway pivotal for cell growth and metabolic regulation. Through this pathway hnRNP Q associates with proteins like mTOR and RAPTOR which aid in nutrient sensitivity adaptation. Additionally it contributes to the mRNA surveillance pathways ensuring the maintenance of RNA quality control mechanisms in the cell.\u003cbr\u003e\nHnRNP Q shows a significant relationship with neurodegenerative diseases and cancer. Alterations in its expression or function associate with disorders like Amyotrophic Lateral Sclerosis (ALS) and various carcinomas. For instance changes in hnRNP Q levels can influence the cellular management of stress responses and apoptosis often via interactions with proteins like TDP-43 and FUS which are implicated in ALS pathogenesis. Additionally upregulation of hnRNP Q in certain cancers has been linked to increased tumorigenic potential and altered cellular metabolism suggesting its potential as a therapeutic target.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851743023273,"sku":"ab250785","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab250785","provider":"Iright","version":"1.0","type":"link"}