{"product_id":"abcam-ab250870","title":"Abcam, ab250870, Anti-SMYD1 antibody [EPR13573] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal SMYD1 antibody. Carrier free. Suitable for WB and reacts with Mouse, Rat, Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR13573,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab250870 is the carrier-free version of\u003cbr\u003e\nab185969\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSET and MYND domain-containing protein 1 (SMYD1) also known as BOP is a protein of approximately 56 kDa that functions as a histone methyltransferase. It modifies histones by transferring methyl groups to specific lysine residues particularly histone H3 at lysine 4 (H3K4). SMYD1 expression is mainly observed in cardiac and skeletal muscle tissues. It plays a role in regulating gene expression by altering chromatin structure therefore influencing transcriptional activity.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSMYD1 plays a significant role in muscle differentiation and development. Its activity leads to chromatin modifications that facilitate muscle-specific gene expression. SMYD1 interacts in a complex network with other proteins involved in muscle function acting as part of the transcriptional machinery that marks certain genes for activation. This methyltransferase activity contributes to the proper formation of muscle fibers.\u003cbr\u003e\nPathways\u003cbr\u003e\nSMYD1 is important in pathways that control heart development and muscle function. It is active in the MAPK signaling pathway which is essential for cell growth and differentiation and interacts with proteins such as MEF2C a transcription factor important for muscle development. This connection influences the regulation and expression of various genes that are critical for normal cardiac and skeletal muscle function.\u003cbr\u003e\nMutations or dysregulation of SMYD1 can lead to congenital heart defects and myopathies. Its interactions with proteins like MYH7 a myosin heavy chain associated with proper cardiac muscle function are important in these conditions. Anomalies in SMYD1 activity can disrupt normal cardiac and skeletal muscle development leading to diseases characterized by structural or functional abnormalities of the heart and muscles.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851014885545,"sku":"ab250870","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab250870","provider":"Iright","version":"1.0","type":"link"}