{"product_id":"abcam-ab251022","title":"Abcam, ab251022, Anti-UQCRB antibody [EPR15591] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal UQCRB antibody. Carrier free. Suitable for ICC\/IF, WB, IHC-P and reacts with Human, Mouse, Rat samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR15591,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WB, ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab251022 is the carrier-free version of\u003cbr\u003e\nab190360\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nUQCRB also known as ubiquinol-cytochrome c reductase binding protein is an important component of the mitochondrial electron transport chain specifically within the complex III (or cytochrome bc1 complex) of mitochondria. This protein has a molecular mass of approximately 14 kDa. It is localized in the inner membrane of mitochondria and is expressed in various tissues with high energy demands such as the heart liver and muscle tissues. UQCRB plays a significant mechanical role in transporting electrons from ubiquinol to cytochrome c a critical step in cellular respiration.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe ubiquinol-cytochrome c reductase binding protein participates in facilitating efficient electron transfer within complex III. As a constituent of the cytochrome bc1 complex UQCRB contributes to the formation of a proton gradient across the mitochondrial membrane which is necessary for the production of ATP. This process is part of oxidative phosphorylation the principal pathway for energy generation in eukaryotic cells. UQCRB interacts closely with other components of the complex III such as cytochrome b and cytochrome c1 ensuring proper electron flow and energy transduction.\u003cbr\u003e\nPathways\u003cbr\u003e\nUQCRB has a pronounced role in the oxidative phosphorylation pathway. This pathway is fundamental in the synthesis of ATP the energy currency in cells through the chemiosmotic coupling of electron transport and phosphorylation. UQCRB serves as a bridging protein for the coherent transfer of electrons from NADH:ubiquinone oxidoreductase (complex I) and succinate dehydrogenase (complex II) towards the cytochrome c oxidase (complex IV). It is intricately linked to other mitochondrial proteins like cytochrome c and ATP synthase that play roles in energy conversion and utilization.\u003cbr\u003e\nUQCRB is associated with mitochondrial disorders specifically with mitochondrial complex III deficiency. This condition has been implicated in various pathologies including Leigh syndrome a severe neurological disorder. Mutations in the UQCRB gene can impair electron transport leading to insufficient ATP production and increased production of reactive oxygen species which contribute to cellular damage. UQCRB's association with other components of complex III such as cytochrome b may exacerbate these deficiencies and highlight its potential as a therapeutic target for mitochondrial dysfunction-related diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46856115814569,"sku":"ab251022","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab251022","provider":"Iright","version":"1.0","type":"link"}