{"product_id":"abcam-ab251075","title":"Abcam, ab251075, Anti-eIF3g antibody [EPR16146] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal EIF3G antibody. Carrier free. Suitable for ICC\/IF, WB, Flow Cyt (Intra), IHC-P and reacts with Human, Rat, Mouse samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR16146,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Rat, Human, Mouse,\u003cbr\u003e\nApplications:IHC-P, WB, ICC\/IF, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab251075 is the carrier-free version of\u003cbr\u003e\nab191422\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe eIF3g also known as eukaryotic translation initiation factor 3 subunit G is a part of the eIF3 complex. It has a mass of approximately 39 kDa. This protein is expressed in various tissues throughout the body. Mechanically eIF3g participates in the process of initiation during protein synthesis by binding to the small ribosomal subunit and assisting in the recruitment of mRNA and initiator tRNA. This helps in the assembly of the functional ribosome making the translation process efficient.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nEIF3g plays an important role in gene expression by being part of the eIF3 complex which is important for starting translation. As a component of the eIF3 complex eIF3g influences cell growth differentiation and survival by regulating the protein synthesis rates. Researchers have identified that its presence in multiple tissues is essential for the proper functioning of cellular activities indicating its broad importance in maintaining cellular physiology.\u003cbr\u003e\nPathways\u003cbr\u003e\nExperts recognize that eIF3g is integral to the mTOR signaling pathway which governs cell growth in response to nutrient availability. It also plays a significant role in the regulation of the EIF4E activity an important protein in initiating translation. eIF3g influences these pathways by acting together with other subunits of the eIF3 complex and interacting with translation-related proteins.\u003cbr\u003e\nDisruptions in eIF3g function link to certain cancers such as breast cancer where increased expression levels of eIF3g have been associated with tumor progression. Additionally abnormalities in eIF3g may contribute to neurodegenerative diseases like Alzheimer's disease given its role in protein synthesis and cell survival. In these contexts eIF3g operates alongside proteins like eIF4E and the eIF3 complex to influence disease development and progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851017801897,"sku":"ab251075","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab251075","provider":"Iright","version":"1.0","type":"link"}