{"product_id":"abcam-ab251089","title":"Abcam, ab251089, Anti-MAGEA9 antibody [EPR16258] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal MAGEA9 antibody. Carrier free. Suitable for IP, WB, Flow Cyt (Intra) and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR16258,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IP, Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab251089 is the carrier-free version of\u003cbr\u003e\nab191568\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMAGEA9 also known as Melanoma-associated antigen family A 9 is a protein encoded by the MAGEA9 gene. This protein has a molecular mass of approximately 36 kDa. MAGEA9 is mainly expressed in testis and certain tumors making it a cancer\/testis (CT) antigen. The specificity of this expression pattern makes MAGEA9 a valuable target in cancer research especially for immunotherapy approaches.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMAGEA9 functions as an element facilitating cellular processes like proliferation and apoptosis. Although MAGEA9 itself is not part of any known complex its expression can influence the regulatory mechanisms within cells supporting cellular survival and growth under oncogenic stress. It has roles in modifying the transcriptional activity affecting genes involved in cell cycle regulation.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe involvement of MAGEA9 extends to the p53 pathway and the MAPK signaling pathway both critical for cell cycle and survival regulation. In the p53 pathway MAGEA9 can interfere with normal p53 function which is vital for DNA damage response and apoptosis. MAGEA9 may interact indirectly with proteins such as p21 a well-known downstream effector of p53 impacting the pathway's ability to manage cell cycle arrest and maintain genomic stability.\u003cbr\u003e\nMAGEA9 holds significant relevance in cancers particularly melanoma and lung cancer. The aberrant expression of MAGEA9 in these diseases highlights its potential utility in diagnostic and therapeutic applications. MAGEA9 expression has been linked with poor prognosis due to its potential to alter pathways related to cell death and proliferation. In some contexts MAGEA9 possibly interacts with other proteins like MAGEA4 which may collectively contribute to oncogenesis and tumor progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851887333545,"sku":"ab251089","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab251089","provider":"Iright","version":"1.0","type":"link"}