{"product_id":"abcam-ab251143","title":"Abcam, ab251143, Anti-NLP1 antibody [EPR16545] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal NLP1 antibody. Carrier free. Suitable for IP, WB, ICC\/IF, IHC-P and reacts with Human, Rat, Mouse samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR16545,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:ICC\/IF, IHC-P, IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab251143 is the carrier-free version of\u003cbr\u003e\nab192609\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe NLP1 protein also known as nlp1 or nuclear localized protein 1 is a significant component in cellular processes. It has a molecular weight of approximately 25 kDa. Expression of NLP1 occurs mainly in the nucleus where it performs important tasks at the molecular level. It participates in various cellular functions by interacting with different molecules within the cell. The proper functioning and localization of NLP1 in the nucleus are important for its role in maintaining cellular integrity and response.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis protein influences gene expression regulation by being part of transcriptional complexes. It interacts with other nuclear proteins to mediate the transcription of specific genes. Participation of NLP1 in these complexes allows it to influence cellular growth and differentiation processes. By controlling these functions NLP1 plays a significant part in the cellular response to external stressors indicating its role in adaptive cellular mechanisms.\u003cbr\u003e\nPathways\u003cbr\u003e\nNLP1 integrates into transcriptional regulation pathways and cell cycle control pathways. In these pathways NLP1 closely interacts with proteins like cyclin-dependent kinases (CDKs) to affect the progression of the cell cycle. This interaction helps regulate important phases in the cell cycle and ensures that cells divide correctly. The involvement of NLP1 in these pathways is notable for maintaining normal cellular function and response.\u003cbr\u003e\nNLP1 shows associations with cancer and neurological disorders. In cancer the dysregulation of NLP1 along with aberrant CDK activity can lead to unchecked cell proliferation. In neurological disorders altered gene expression caused by dysfunctional NLP1 activity can result in disrupted neural processes. These connections highlight the potential of NLP1 as a target for therapeutic interventions seeking to prevent or treat these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851631481001,"sku":"ab251143","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab251143","provider":"Iright","version":"1.0","type":"link"}