{"product_id":"abcam-ab251147","title":"Abcam, ab251147, Anti-UCHL5IP antibody [EPR15341-56] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal UCHL5IP antibody. Carrier free. Suitable for IP, WB, Flow Cyt (Intra), IHC-P and reacts with Human, Mouse samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR15341-56,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:IHC-P, Flow Cyt (Intra), WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab251147 is the carrier-free version of\u003cbr\u003e\nab192616\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nUCHL5IP also known as Ubiquitin Carboxyl-terminal Hydrolase L5 Interacting Protein functions as an important protein supporting the role of UCHL5 in protein degradation. UCHL5IP is involved in deubiquitination processes and has closely-related functions with enzymes in removing ubiquitin from proteins. Its molecular mass is approximately 26 kDa. UCHL5IP is broadly expressed in various tissues suggesting its involvement in several cellular processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nUCHL5IP regulates protein turnover by assisting the function of UCHL5. It forms part of a complex with the proteasome which is important for maintaining protein homeostasis. This interaction helps the proteasome properly degrade misfolded or excessive proteins enhancing cellular regulation. The involvement of UCHL5IP in maintaining protein quality control underlines its significance in cellular integrity and function.\u003cbr\u003e\nPathways\u003cbr\u003e\nScientists recognize UCHL5IP's participation in the ubiquitin-proteasome pathway a major cellular mechanism controlling protein degradation. It interacts with UCHL5 a component of the protease interacting with the proteasome. The pathway is responsible for regulating protein levels and maintaining cellular balance. Additionally UCHL5IP might have connections to signaling pathways through roles in modulating protein levels linking it to broader networks of cellular communication and response.\u003cbr\u003e\nResearchers have linked UCHL5IP to neurodegenerative diseases due to its involvement in proteasome function. Malfunction in protein degradation pathways contributes to disorders such as Parkinson’s disease. UCHL5IP through its interaction with UCHL5 can influence the build-up of misfolded proteins which are necessary for disease development. Continued study on UCHL5IP might provide further insights into its role in these conditions and potential therapeutic targets.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46860416057513,"sku":"ab251147","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab251147","provider":"Iright","version":"1.0","type":"link"}