{"product_id":"abcam-ab251194","title":"Abcam, ab251194, Anti-MRPL48 antibody [EPR16328] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal MRPL48 antibody. Carrier free. Suitable for ICC\/IF, IP, WB, Flow Cyt (Intra), IHC-P and reacts with Human, Mouse, Rat samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR16328,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Rat, Human, Mouse,\u003cbr\u003e\nApplications:IP, IHC-P, Flow Cyt (Intra), WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab251194 is the carrier-free version of\u003cbr\u003e\nab194826\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMRPL48 also known as mitochondrial ribosomal protein L48 is a component of the mitochondrial ribosome. This protein has a mass of approximately 18.7 kDa and plays a role in protein synthesis within mitochondria. MRPL48 locates itself mostly in the mitochondria of cells across various tissues with higher expression levels observed in tissues with high energy demands such as muscle and liver.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMRPL48 contributes to the formation and function of the mitochondrial ribosome which is responsible for synthesizing proteins that are essential for mitochondrial respiration and energy production. This protein is part of the large subunit of the mitochondrial ribosome which includes many other mitochondrial ribosomal proteins. Together they form a complex responsible for translating mitochondrial mRNA into functional proteins.\u003cbr\u003e\nPathways\u003cbr\u003e\nMRPL48 is actively engaged in mitochondrial translation a critical pathway for maintaining mitochondrial function and energy production. In this pathway it associates with other mitochondrial ribosomal proteins to produce enzymes necessary for the electron transport chain and ATP synthesis. MRPL48 also relates to oxidative phosphorylation where it plays a part in generating cellular energy linking it to proteins such as cytochrome c oxidase subunit IV.\u003cbr\u003e\nDefects in MRPL48 could relate to mitochondrial dysfunctions which may contribute to disorders like mitochondrial myopathy and mitochondrial complex I deficiency. These conditions often manifest muscle weakness neurological problems and metabolic disturbances. In these disorders MRPL48's interaction with other mitochondrial ribosomal proteins is important as impaired mitochondrial protein synthesis can cause decreased energy production and increased oxidative stress within cells.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851631513769,"sku":"ab251194","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab251194","provider":"Iright","version":"1.0","type":"link"}