{"product_id":"abcam-ab251226","title":"Abcam, ab251226, Anti-SNAPC1 antibody [EPR16466] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal SNAPC1 antibody. Carrier free. Suitable for ICC\/IF, WB, Flow Cyt (Intra) and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR16466,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:Flow Cyt (Intra), ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab251226 is the carrier-free version of\u003cbr\u003e\nab197015\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSNAPC1 also known as small nuclear RNA activating complex polypeptide 1 is a component of the snRNA-activating protein complex. It has a mass of about 43 kDa. SNAPC1 plays an important role in the transcription initiation of small nuclear RNA (snRNA) genes. It functions through interaction with other components of the SNAPc complex. Researchers observe its expression in various tissues but it appears particularly active in cells with high transcriptional demand.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe role of SNAPC1 lies in the assembly and regulation of the SNAPc complex. This complex functions primarily in the transcription of snRNA essential for mRNA processing and gene expression regulation. By participating in the formation of the snRNA-activating protein complex SNAPC1 facilitates the correct transcription and processing of snRNA a critical component in the spliceosomal machinery. It achieves this by forming stable interactions with other SNAPc components including SNAPC2 and SNAPC3 contributing to pre-mRNA splicing.\u003cbr\u003e\nPathways\u003cbr\u003e\nSNAPC1 integrates into two major cellular pathways: transcription initiation and RNA splicing. It closely interacts with elements such as RNA polymerase II and SNAPC4 within these pathways. By securing a stable interaction with these elements SNAPC1 supports efficient transcription of snRNA and its subsequent processing. The proper function of SNAPC1 and related proteins ensures the accuracy of mRNA splicing impacting overall gene expression and cellular function.\u003cbr\u003e\nDefects or dysregulations involving SNAPC1 can link to disorders like Spinal Muscular Atrophy (SMA) and systemic lupus erythematosus (SLE). In SMA disruptions in snRNA processing lead to defects in the creation of essential proteins needed for motor neuron survival wherein SNAPC1 may hold a supporting role. In SLE abnormal snRNA processing can contribute to the production of autoantibodies linking SNAPC1 to the autoimmune pathway. SNAPC1's functional interactions with proteins like SMN (Survival of Motor Neuron) protein in SMA further illustrate its involvement in these disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851871211689,"sku":"ab251226","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab251226","provider":"Iright","version":"1.0","type":"link"}