{"product_id":"abcam-ab251259","title":"Abcam, ab251259, Anti-Annexin-7\/ANXA7 antibody [EPR16173] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal Annexin-7\/ANXA7 antibody. Carrier free. Suitable for IP, WB, IHC-P and reacts with Human, Mouse, Rat samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR16173,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WB, IHC-P, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab251259 is the carrier-free version of\u003cbr\u003e\nab198990\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAnnexin-7 (ANXA7) also known as synexin is a calcium-dependent phospholipid-binding protein. It has a molecular weight of approximately 51 kDa. This protein is expressed in various tissues with notable expression in the heart and brain. Mechanically ANXA7 plays a role in membrane fusion and exocytosis which are critical processes for cellular communication and transport.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nAnnexin-7 functions as an important player in cell proliferation and signal transduction. It forms part of the annexin family of proteins which are known for their role in calcium ion binding and membrane-related activities. Annexin-7 has a role in linking Ca2+ signaling with phospholipid membrane dynamics which suggests its involvement in cellular events like growth and differentiation.\u003cbr\u003e\nPathways\u003cbr\u003e\nAnnexin-7 influences both the MAPK and EGFR signaling pathways. These pathways are essential for regulating cell division apoptosis and cellular response to external stimuli. Within these pathways Annexin-7 interacts with proteins such as Ras and PI3K which are important for propagating signals that control cellular behaviors.\u003cbr\u003e\nAbnormalities in Annexin-7 expression and function associate it with cancer and schizophrenia. In cancer altered ANXA7 function may disrupt normal cell communication and growth pathways contributing to tumorigenesis. In schizophrenia disrupted calcium signaling involving ANXA7 may affect neuronal communication and brain function. In these conditions Annexin-7 interacts with proteins like p53 and NMDA receptors which are critical to the pathology of cancer and neurological disorders respectively.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848519241897,"sku":"ab251259","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab251259","provider":"Iright","version":"1.0","type":"link"}