{"product_id":"abcam-ab251335","title":"Abcam, ab251335, Anti-Amyloid Fibril antibody [mOC87] - BSA and Azide free","description":"Size: 100µg \/ 1mg\nRabbit Recombinant Monoclonal Amyloid-beta precursor protein antibody. Carrier free. Suitable for IHC-P, IHC-FrFl, Dot and reacts with Human, Mouse, Synthetic peptide samples. Cited in 1 publication.\nKey facts\nHost species:Rabbit,\nClonality:Monoclonal,\nClone number:mOC87,\nIsotype:IgG,\nCarrier free:Yes,\nReacts with:Mouse, Human,\nApplications:IHC-FrFl, IHC-P, DotSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\n\nProduct details:\nab251335 is the carrier-free version of\nab201062\nThis antibody was developed as part of a collaboration between Abcam and Professor Charles Glabe, UC Irvine.\nab251335 recognizes a generic epitope of amyloid fibrils and oligomers that is independent of linear sequence (Hatami et al 2014, PMID: 25281743). Its reactivity with AΒ monomer and oligomers is decreased or eliminated upon thermal denaturation at 100°C of AΒ in SDS sample buffer on western blots (Hatami et al 2014, PMID: 25281743).\nFor further information on the immunogen, please refer to Hatami et al 2014, PMID: 25281743 and \u003ckayed et al. patented technology our rabmab is a hybridoma-based for making rabbit monoclonal antibodies. details on patents please refer to what are the advantages of recombinant antibody this product which offers several high batch-to-batch consistency and reproducibility improved sensitivity specificity long-term security supply animal-free batch production more information read antibodies conjugation ready carrier-free typically supplied in pbs-only formulation purified free bsa sodium azide glycerol. conjugation-ready format designed use with fluorochromes metal isotopes oligonucleotides enzymes makes them ideal labelling functional cell-based assays flow-based mass cytometry multiplex imaging applications. kits conjugates that ready-to-use as little minutes minute hands-on-time available fluorescent dyes hrp biotin gold. compatibility compatible maxpar labeling kit from fluidigm without need preparation. trademark canada inc. properties storage form-liquid purification technique-affinity protein pbs shipped at conditions-blue ice appropriate short-term conditions- information-do not freeze supplementary collated multiple sources compiled automatically. amyloid fibrils alternatively named fibrillar insoluble fibrous aggregates resulting abnormal folding proteins. they compose primarily beta-sheet structures promote stability rigidity. frequently associated proteins like tau known their molecular mass. researchers observe these various tissues where exhibit significant resilience both chemical enzymatic degradation. biological function summary misfolding accumulation into prove disruptive within cells. often form part complex assemblies interfere normal cellular functions. disruption further leads dysfunction death. while commonly observed neuronal cells linked neurodegenerative conditions can also appear other organs suggesting multi-systemic implications. pathways scientists recognize involvement amyloidogenic pathways. lead generation misfolded precursor presenilins play important roles pathway processes fibrils. addition influence calcium dysregulation oxidative stress contributing altered homeostasis. strongly alzheimer disease systemic amyloidosis. formed by peptides contribute plaque formation hallmark condition. furthermore interactions exacerbate neurofibrillary tangles compounding effects. amyloidosis different undergo fibrillogenesis widespread organ highlighting pathogenic potential beyond neurological tissues. pmid:=\"\" including:=\"\" recovery:=\"\" information:=\"\" buffer-ph:=\"\" constituents:=\"\"\u003e\u003c\/kayed\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851018784937,"sku":"ab251335","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab251335","provider":"Iright","version":"1.0","type":"link"}