{"product_id":"abcam-ab251377","title":"Abcam, ab251377, Anti-TCTEX-1 antibody [EPR17294] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal TCTEX-1 antibody. Carrier free. Suitable for IP, WB, ICC\/IF, Flow Cyt (Intra), IHC-P and reacts with Human, Mouse samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR17294,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:IHC-P, Flow Cyt (Intra), WB, ICC\/IF, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab251377 is the carrier-free version of\u003cbr\u003e\nab202583\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTCTEX-1 also known as DYNLT1 or DLC1 is a component of the cytoplasmic dynein motor protein complex. It has a molecular mass of approximately 14 kDa. This protein localizes mainly to the cytoplasm and is expressed in a variety of tissues including the brain and kidneys. TCTEX-1 interacts with other proteins to facilitate cellular transport along microtubules which are essential components of the cell’s cytoskeleton aiding in maintaining cell shape and facilitating organelle movement.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe role of TCTEX-1 involves the transport of vesicles and other cargo within cells using the dynein motor complex. This protein is a light chain component of the dynein which is a cytoplasmic motor protein complex responsible for retrograde transport movement along microtubules. It ensures the efficient transfer of intracellular organelles playing an essential role in cellular organization and function.\u003cbr\u003e\nPathways\u003cbr\u003e\nTCTEX-1's involvement spans the intracellular trafficking and signaling pathways. It participates significantly in the endocytic pathway working closely with proteins like dynein heavy chain to mediate the efficient movement of endosomes. TCTEX-1 is also linked to the Wnt signaling pathway where its association with microtubule dynamics assists in cell signaling processes and influences cellular responses.\u003cbr\u003e\nTCTEX-1 shows associations with neurodegenerative diseases such as Alzheimer's disease. Disruption in its function can lead to impaired axonal transport contributing to the pathological development of neurodegeneration. Additionally aberrant expression of TCTEX-1 is connected to certain types of renal cancer where interactions with proteins like BCL2L2 can influence cell survival and apoptosis pathways in tumor cells.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851610968233,"sku":"ab251377","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab251377","provider":"Iright","version":"1.0","type":"link"}