{"product_id":"abcam-ab251404","title":"Abcam, ab251404, Anti-ACTR1B + ACTR1A antibody [EPR16968(B)] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal ACTR1B antibody. Carrier free. Suitable for IP, WB and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR16968(B),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab251404 is the carrier-free version of\u003cbr\u003e\nab203833\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nACTR1A and ACTR1B also known as Actin-related protein 1A and 1B play roles in cellular processes by interacting with the cytoskeleton. While ACTR1A has a mass of approximately 42 kDa ACTR1B weighs around 48 kDa. Both proteins have widespread expression in multiple tissue types where they influence cellular structure and dynamics. They are especially important in cells undergoing rapid movement or growth.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThese proteins contribute to cytoskeletal remodeling processes essential for cellular functions. They act as components of the dynactin complex which associates with microtubules to regulate intracellular transport. Their activity is important for cellular activities that involve cytoplasmic organization including endocytosis and the distribution of organelles. The effective functioning of ACTR1A and ACTR1B supports cellular responses to external stimuli and environmental changes.\u003cbr\u003e\nPathways\u003cbr\u003e\nACTR1A and ACTR1B engage in the regulation of the MAPK and Actin cytoskeleton pathways. Within these pathways they work with proteins such as DYNLL1 and DCTN1 to facilitate these cellular processes. The ACTR1A and ACTR1B proteins ensure proper cellular responses to signaling cues that can impact cell fate and behavior through these pathways.\u003cbr\u003e\nACTR1A and ACTR1B have connections to neurodegenerative diseases like Alzheimer's and certain types of cancer. Related to Alzheimer's changes in the function or expression of ACTR1A and ACTR1B can influence pathways involved in neuronal damage and synapse loss. For cancer their role in cell motility and division is significant with alterations linked to metastasis and tumor progression. Their interaction with proteins like tau in Alzheimer's and oncogenes in cancer reflects the complexity of their involvement in disease contexts.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851261431977,"sku":"ab251404","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab251404","provider":"Iright","version":"1.0","type":"link"}