{"product_id":"abcam-ab251756","title":"Abcam, ab251756, Anti-RAB11FIP1 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal RAB11FIP1 antibody. Suitable for IHC-P, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RAB11FIP1 aa 750-850.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human RAB11FIP1 aa 750-850. The exact immunogen used to generate this antibody is proprietary information.Q6WKZ4\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nRAB11FIP1 also known as Rab11 Family Interacting Protein 1 or pp75 is a protein that plays an important role in membrane trafficking. It acts as an effector molecule for Rab11 a small GTPase involved in the regulation of vesicle recycling. RAB11FIP1 has a mass of about 90 kDa and gets expressed in many tissues including brain liver and kidney. It contains regions critical for its interaction with Rab11 facilitating cargo sorting and transport within the endosomal recycling system.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nRAB11FIP1 is involved in several cellular functions related to endosomal transport and recycling processes. It is part of the recycling endosome complex where it helps in the sorting and delivery of cargo to the plasma membrane. The protein contributes to processes like insulin-stimulated glucose transporter 4 translocation and transferrin receptor recycling indicating its role in important cellular functions. It also associates with various other proteins to ensure efficient endocytic and exocytic pathway operations.\u003cbr\u003e\nPathways\u003cbr\u003e\nRAB11FIP1 has significant roles in processes like the endocytic recycling pathway and the trans-Golgi network. Its interaction with Rab11 is part of the broader trafficking network regulating endocytic recycling critical for maintaining cell surface receptor levels. It is also linked with other proteins such as EHD1 known for their roles in endosomal transport highlighting its involvement in maintaining intracellular homeostasis and efficient transport of cellular material.\u003cbr\u003e\nRAB11FIP1 contributes to conditions such as cancer and neurological disorders. Alterations in its function can disturb membrane trafficking pathways affecting processes like cell migration and proliferation linked to cancer development. Additionally its interactions with proteins such as E-cadherin important for cell adhesion further connect RAB11FIP1 to cancer progression. The protein is also implicated in neurological disorders due to its significant role in vesicle trafficking in neurons affecting synaptic function and potentially contributing to neurodegenerative diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854244040873,"sku":"ab251756","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab251756","provider":"Iright","version":"1.0","type":"link"}