{"product_id":"abcam-ab251840","title":"Abcam, ab251840, Anti-MOXD1\/MOX antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal MOXD1\/MOX antibody. Suitable for IHC-P, ICC\/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human MOXD1 aa 100-250.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human MOXD1 aa 100-250. The exact immunogen used to generate this antibody is proprietary information.Q6UVY6\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMOXD1 also known as monooxygenase DBH-like 1 or MOX is a member of the copper type II ascorbate-dependent monooxygenase family. It functions mechanistically by catalyzing the hydroxylation of its substrates a process essential for certain biochemical conversions. The mass of MOXD1 is approximately 82 kDa. MOXD1 expresses prominently in the central nervous system particularly in the brain and can also be found in other tissues at varying levels.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe enzyme MOXD1 plays a role in neuroactive substrate modifications contributing to neurotransmitter biosynthesis. MOXD1 does not form a known complex but interacts with copper ions that act as cofactors which are necessary for its enzymatic activity. The action of MOXD1 impacts cellular processes by regulating key elements within the neurochemical framework aiding in overall neuronal function.\u003cbr\u003e\nPathways\u003cbr\u003e\nMOXD1 integrates into the catecholamine biosynthetic pathway. This pathway is significant for the production of amine neurotransmitters such as dopamine and norepinephrine. MOXD1 relates to dopamine beta-hydroxylase (DBH) another enzyme in this pathway that also uses copper as a cofactor. Both enzymes contribute to the maintenance of catecholamine balance in the nervous system.\u003cbr\u003e\nMOXD1 shows connections with neurological conditions such as depression and neurodegenerative diseases. Changes in MOXD1 expression or function may influence neurotransmitter levels potentially impacting mood and cognitive functions. Studies have suggested a relationship between MOXD1 and dopamine-related disorders through its connection to DBH which has been implicated in the pathophysiology of certain mental health conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854244008105,"sku":"ab251840","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab251840","provider":"Iright","version":"1.0","type":"link"}