{"product_id":"abcam-ab251954","title":"Abcam, ab251954, Anti-FOXN3 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal FOXN3 antibody. Suitable for IHC-P, ICC\/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human FOXN3 aa 1-100.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human FOXN3 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.O00409\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nFOXN3 also known as Forkhead Box N3 is a transcription factor that regulates transcription of target genes. The protein belongs to the family of forkhead box transcription factors and possesses a conserved DNA-binding domain. FOXN3 has an approximate molecular weight of 74 kDa. It is expressed in various tissues including the liver heart and kidneys. This protein contributes significantly to cellular stress responses and developmental processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nFOXN3 modulates gene expression related to cell cycle control and apoptosis. It acts within a complex to influence the stability and transcriptional activity of other proteins. As part of the MLL complex FOXN3 co-regulates gene expression essential for hematopoietic stem cell maintenance. Through controlling specific target genes it plays a critical role in development and differentiation impacting both normal physiological processes and pathological conditions.\u003cbr\u003e\nPathways\u003cbr\u003e\nFOXN3 is involved in the regulation of the p53 pathway a critical pathway for tumor suppression and cell cycle control. The protein collaborates with p53 to manage stress-induced transcriptional responses. In the NF-kB signaling pathway FOXN3 regulates immune and inflammatory responses positioning itself as an important mediator of immune functions. It interplays with proteins like MLL and p21 emphasizing its significance in these pathways.\u003cbr\u003e\nFOXN3 associates with cancer particularly breast cancer contributing to its development and progression through aberrant regulation of cell cycle genes. Dysregulation of FOXN3 links to developmental disorders impacting genes that are essential during embryogenesis. In cancer FOXN3 interacts with proteins like BRCA1 amplifying the effects of its dysfunction in tumorigenesis.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848599064745,"sku":"ab251954","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab251954","provider":"Iright","version":"1.0","type":"link"}