{"product_id":"abcam-ab252269","title":"Abcam, ab252269, Anti-TCF12 antibody [7B3] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRat Recombinant Monoclonal TCF12 antibody. Carrier free. Suitable for WB and reacts with Mouse, Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rat,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:7B3,\u003cbr\u003e\nIsotype:IgG2b,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab252269 is the carrier-free version of\u003cbr\u003e\nab243149\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nWant a custom formulation?\u003cbr\u003e\nThis antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTCF12 also known as transcription factor 12 or Heb functions as a basic helix-loop-helix (bHLH) transcription factor. It plays roles in DNA binding and regulation of gene expression. The protein has a molecular mass of approximately 75 kDa. TCF12 expresses in various tissues with notable levels observed in the brain and skeletal muscle. It influences the development and differentiation of different cell types due to its transcriptional regulation activities.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTCF12 controls the transcription of genes involved in cellular differentiation proliferation and development. It frequently functions as part of heterodimeric complexes with other bHLH proteins such as E2A. These complexes allow TCF12 to regulate a variety of target genes involved in tissue development and cell fate decisions. TCF12's ability to form these complexes enhances its functional diversity and impact on biological processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe role of TCF12 extends to the Notch signaling pathway where it interacts with proteins like Notch receptors to affect cell fate determination. The protein also participates in the Myogenesis pathway collaborating with MyoD to facilitate the differentiation of myoblasts into mature muscle fibers. These pathways highlight TCF12's involvement in developmental processes and lineage specification.\u003cbr\u003e\nTCF12 mutations and dysregulation have associations with craniosynostosis a condition characterized by premature fusion of cranial sutures. TCF12 also relates to certain types of cancer due to its regulatory effects on cell proliferation. In these contexts TCF12 may interact with proteins like TWIST1 which also influences developmental and tumorigenic processes highlighting potential therapeutic targets for intervention.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855460290729,"sku":"ab252269","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab252269","provider":"Iright","version":"1.0","type":"link"}