{"product_id":"abcam-ab252765","title":"Abcam, ab252765, Anti-Influenza B Virus Nucleoprotein antibody [B312M]","description":"\u003cp\u003eSize: 250µg\u003cbr\u003e\nMouse Monoclonal NCAP antibody. Cited in 1 publication. Immunogen corresponding to Virus preparation containing Influenza B Virus Nucleoprotein protein.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:B312M,\u003cbr\u003e\nIsotype:IgG2b,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:Influenza B Virus nucleoprotein (species specific conserved epitope).\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Purification notes-\u0026gt;90% pure (SDS-PAGE). Purified from tissue culture supernatant., Storage buffer-Preservative: 0.0975% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe Influenza B Virus Nucleoprotein often known as NP or flu B NP is an essential structural protein with a molecular weight of approximately 56 kDa. It plays a role in the influenza B virus lifecycle by encapsidating the viral RNA forming the ribonucleoprotein complex important for viral replication and transcription. This protein expresses in the host cell's cytoplasm and nucleus facilitating the export of vRNPs from the nucleus.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe ribonucleoprotein complex formation involves nucleoproteins assembling with the viral RNA and polymerase subunits securing the genome for replication and transcription. NP interacts with both the polymerase basic 2 (PB2) and polymerase acidic (PA) proteins forming a vital part of the complex. This interaction allows the viral RNA to maintain its structure and function effectively during the virus infection cycle aiding both Influenza A and B viruses.\u003cbr\u003e\nPathways\u003cbr\u003e\nNP participates in the viral replication pathway supporting the influenza virus propagation in infected cells. It associates closely with viral RNA polymerases and is integral to the transcription and replication of the viral RNA genome. Other key proteins involved in these pathways include the polymerase basic 1 (PB1) protein essential for synthesizing viral mRNA and the matrix protein (M1) which aids in vRNA encapsidation and budding.\u003cbr\u003e\nNP relates closely to influenza B infections contributing to the clinical symptoms of flu B such as fever and respiratory issues. This protein is also a potential target for vaccine and therapeutic development against influenza B. NP shares a connection with the M2 protein another target in antiviral strategies given its role in proton channel activity and viral uncoating. Understanding NP's role can guide the creation of flu B antibodies and influenza A and B antibodies to reduce disease severity or prevent flu infections.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855443087529,"sku":"ab252765","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab252765","provider":"Iright","version":"1.0","type":"link"}