{"product_id":"abcam-ab254260","title":"Abcam, ab254260, Anti-Orai3 antibody [EPR22575-17]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal ORAI3 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 5 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR22575-17,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nOrai3 is a protein known as a part of the calcium release-activated calcium (CRAC) channel family. It is also referred to as Orai calendar in certain contexts. This protein serves as a critical component in the highly selective process of calcium ion entry across the plasma membrane. Orai3 has a mass of approximately 33 kDa. It is expressed predominantly in tissues like the pancreas lung and immune system which often require tight regulation of calcium homeostasis for their proper function.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nOrai3 plays an essential role in cellular calcium signaling important for various cell functions such as gene expression secretion and metabolism. It often combines with other subunits of the Orai family like Orai1 to form functional calcium channels. Orai3 may form different channel complexes affecting the amplitude and kinetics of calcium entry. Its presence ensures that cells can adapt to specific physiological contexts where calcium influx is required.\u003cbr\u003e\nPathways\u003cbr\u003e\nOrai3 is a significant part of the store-operated calcium entry (SOCE) pathway which activates when intracellular calcium stores get depleted. This pathway is important for maintaining cellular calcium and proteins like STIM1 work closely with Orai3 to initiate calcium influx. The interplay between STIM1 and Orai3 ensures proper signal transduction essential for processes like T-cell activation and other immune responses.\u003cbr\u003e\nOrai3 has implications in certain cancers and cardiovascular diseases. In some cancer types like breast cancer overexpression of Orai3 contributes to cell proliferation and survival which can lead to tumor progression. Similarly in cardiovascular diseases altered function or expression of Orai3 may impact calcium regulation leading to issues such as hypertension. Its association with STIM1 in these disorders highlights the cooperative role they play in maintaining cellular health emphasizing the importance of regulated calcium influx in normal and disease states.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850328723625,"sku":"ab254260","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab254260","provider":"Iright","version":"1.0","type":"link"}