{"product_id":"abcam-ab254395","title":"Abcam, ab254395, GSK872, Necroptosis inhibitor","description":"\u003cp\u003eSize: 5mg \/ 25mg\u003cbr\u003e\nMW 383.5 Da, Purity \u0026gt;98%. Highly potent, selective receptor interacting protein 3 (RIP3) inhibitor (IC50 = 1.3nM). Selectivty for RIP3 is over 100-fold more compared to other kinases. At high concentrations (3-10μM) can induce Caspase 8-mediated apoptosis. Increases HIF-1a expression after ischaemic injury *in vivo*. Blocks necroptosis in primary human neutrophils, TNF-induced necroptosis in HT-29 cells and inhibits TLR3- and DAI-induced death *in vitro.*.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:1346546-69-7,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:383.5 Da,\u003cbr\u003e\nMolecular formula:C19H17N3O2S2,\u003cbr\u003e\nPubChem:54674134,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO up to 50mM,\u003cbr\u003e\nBiochemical name:N-(6-propan-2-ylsulfonylquinolin-4-yl)-1,3-benzothiazol-5-amine,\u003cbr\u003e\nBiological description:Highly potent, selective receptor interacting protein 3 (RIP3) inhibitor (IC50 = 1.3nM). Selectivty for RIP3 is over 100-fold more compared to other kinases. At high concentrations (3-10μM) can induce Caspase 8-mediated apoptosis. Increases HIF-1a expression after ischaemic injury *in vivo*. Blocks necroptosis in primary human neutrophils, TNF-induced necroptosis in HT-29 cells and inhibits TLR3- and DAI-induced death *in vitro.*,\u003cbr\u003e\nCanonical smiles:CC(C)S(=O)(=O)C1=CC2=C(C=CN=C2C=C1)NC3=CC4=C(C=C3)SC=N4,\u003cbr\u003e\nInChi:InChI=1S\/C19H17N3O2S2\/c1-12(2)26(23,24)14-4-5-16-15(10-14)17(7-8-20-16)22-13-3-6-19-18(9-13)21-11-25-19\/h3-12H,1-2H3,(H,20,22),\u003cbr\u003e\nInChiKey:ZCDBTQNFAPKACC-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:N-(6-propan-2-ylsulfonylquinolin-4-yl)-1,3-benzothiazol-5-amine\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nSolutions in DMSO can be stored for up to 1 month.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-The product can be stored for up to 12 months\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847502516393,"sku":"ab254395","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab254395","provider":"Iright","version":"1.0","type":"link"}