{"product_id":"abcam-ab254470","title":"Abcam, ab254470, Anti-ITLN1 + ITLN2 antibody [EPR22491-81] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal ITLN1 antibody. Carrier free. Suitable for WB, IHC-Fr, IHC-P and reacts with Mouse, Rat, Human, Recombinant full length protein - Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR22491-81,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:IHC-Fr, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab254470 is the carrier-free version of\u003cbr\u003e\nab252926\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nITLN1 and ITLN2 also known as intelectin-1 and intelectin-2 are proteins with mass of approximately 35 and 34 kDa respectively. They are secreted glycoproteins primarily expressed in the intestinal tissues with substantial expression in adipose tissue and the respiratory tract as well. These proteins contain a carbohy­drate-binding domain that allows them to bind galactofuranose a sugar present in bacterial cell walls and play a role in host defense.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nIntelectin proteins participate actively in the recognition and binding of microbial pathogens thereby contributing to the innate immune response. They do not form part of larger protein complexes but interact with galactofuranose on pathogens to trigger immune mechanisms. By binding to carbohydrates specific to pathogens they help in the elimination of harmful microorganisms from the body therefore maintaining homeostasis in the host from a microbial perspective.\u003cbr\u003e\nPathways\u003cbr\u003e\nITLN1 and ITLN2 play significant roles in the immune system pathways interacting with related components to enhance pathogen recognition. These proteins modulate the activation of the immune pathway involving toll-like receptors (TLRs) which sense pathogen-associated molecular patterns. ITLN1 and ITLN2 contribute to these pathways alongside TLRs by facilitating enhanced recognition and response to invading pathogens.\u003cbr\u003e\nITLN1 and ITLN2 have associations with inflammatory bowel disease and type 2 diabetes. In inflammatory bowel disease altered expression of these proteins can influence the gut microbiota and immune response linked through interactions with cytokines like TNF-alpha. Similarly in the context of type 2 diabetes altered levels of these proteins in adipose tissue can impact insulin sensitivity also interacting with proteins like adiponectin which plays a role in regulating glucose levels and fatty acid breakdown.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851264610473,"sku":"ab254470","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab254470","provider":"Iright","version":"1.0","type":"link"}