{"product_id":"abcam-ab254588","title":"Abcam, ab254588, Anti-FZD10 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal FZD10 antibody. Suitable for IHC-P, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FZD10 aa 450-500.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human FZD10 aa 450-500. The exact immunogen used to generate this antibody is proprietary information.Q9ULW2\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nFrizzled-10 (FZD10) also known as CD350 is a receptor in the frizzled family of proteins. It acts as a receptor for Wnt signaling proteins typically involved in communications between cells. The receptor belongs to the larger group of G-protein-coupled receptors and contains a seven-transmembrane domain structure. Its molecular mass is about 64 kDa. FZD10 is prominently expressed in various tissues including the brain and certain regions of the gastrointestinal tract with higher expression often seen in fetal tissues compared to adult tissues.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nFZD10 plays a significant role in the Wnt signaling pathway that affects cell development differentiation and proliferation. It usually forms part of a receptor complex that includes other proteins like LRP5\/6 and Dishevelled. The interaction of FZD10 with Wnt ligands activates downstream signaling cascades important for embryonic development and maintaining stem cell states. Its involvement in these processes underlines its role in regulating key cellular dynamics.\u003cbr\u003e\nPathways\u003cbr\u003e\nFZD10 is central to both the canonical Wnt\/β-catenin pathway and non-canonical Wnt pathways. These pathways orchestrate critical cellular functions such as gene expression cytoskeletal arrangement and cellular movement. FZD10 collaborates closely with other frizzled receptors and Wnt proteins like Wnt3a to modulate these pathways. By regulating the stabilization and localization of β-catenin FZD10 influences various downstream target genes essential for cellular activities.\u003cbr\u003e\nFZD10 shows association with certain cancers particularly synovial sarcoma and colon cancer. Misregulated expression of FZD10 contributes to oncogenic processes by abnormally activating Wnt signaling pathways which in turn affects cellular proliferation and survival. Additionally its association with Wnt signaling proteins such as β-catenin in these disease states emphasizes its impact on tumorigenesis and progression. Understanding FZD10's role offers potential therapeutic targets for interventions in cancers where this pathway is implicated.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854226575529,"sku":"ab254588","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab254588","provider":"Iright","version":"1.0","type":"link"}