{"product_id":"abcam-ab254715","title":"Abcam, ab254715, Anti-ZNF503 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal ZNF503 antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ZNF503 aa 100-300.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human ZNF503 aa 100-300. The exact immunogen used to generate this antibody is proprietary information.Q96F45\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nZNF503 also known as Zfp503 or Zeppo1 is a zinc finger protein with a molecular weight of approximately 55 kDa. ZNF503 consists of zinc finger domains which contribute to its function as a transcription factor. This protein is expressed in several tissues including the brain heart and lungs. ZNF503 interacts with DNA to either activate or repress transcription of specific genes controlling various cellular processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nZNF503 plays an important role in the regulation of development and differentiation processes. It often functions as part of a transcriptional regulatory complex. This protein modulates the transcriptional activity affecting gene expression profiles according to the cellular context. It is essential in early embryonic development and neuronal differentiation contributing to the proper formation and function of these tissues.\u003cbr\u003e\nPathways\u003cbr\u003e\nZNF503 is a significant modulator of the Wnt signaling pathway which influences cell growth differentiation and migration. In the context of Wnt signaling ZNF503 interacts with other key proteins such as β-catenin facilitating Wnt pathway regulation. ZNF503 also associates with the Notch signaling pathway where it impacts cellular communication and fate decisions by interacting with components like Notch receptors and ligands.\u003cbr\u003e\nZNF503 has been implicated in cancer and neurodevelopmental disorders. Aberrant expression of ZNF503 is linked to tumorigenesis particularly in breast cancer where it interacts with proteins like HER2 to promote cancerous growth. In developmental disorders such as intellectual disabilities ZNF503 may influence neural development through its interactions with proteins involved in synaptic formation and maintenance leading to cognitive impairments when dysregulated.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854060605609,"sku":"ab254715","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab254715","provider":"Iright","version":"1.0","type":"link"}