{"product_id":"abcam-ab254919","title":"Abcam, ab254919, Anti-C19orf21 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal C19orf21 antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MISP aa 550 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human MISP aa 550 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q8IVT2\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nC19orf21 also known as Chromosome 19 Open Reading Frame 21 is a protein with a molecular mass of approximately 26 kDa. It is expressed in various tissues with significant activity in the spleen and lung. Mechanically C19orf21 functions in nuclear processes including transcription regulation and chromatin remodeling. Due to its involvement in these activities C19orf21 interacts with nuclear components and may impact gene expression by influencing chromatin structure.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nC19orf21 plays a role in regulating cellular homeostasis and proliferation. C19orf21 is part of the chromatin remodeling complex which modifies chromatin to allow access to transcription machinery. This participation suggests importance in controlling gene accessibility. C19orf21's involvement in such intricate processes indicates a possible role in cellular development and differentiation influencing tissue-specific gene expression.\u003cbr\u003e\nPathways\u003cbr\u003e\nC19orf21 is involved in chromatin modification and transcriptional regulation pathways. It interacts with proteins like histone acetyltransferases contributing to epigenetic modifications and regulation of gene expression. Additionally C19orf21 shows involvement in pathways that maintain DNA integrity working alongside proteins like DNA repair enzymes. These interactions suggest that C19orf21 supports cellular responses to damage and stress.\u003cbr\u003e\nC19orf21 has been implicated in certain types of cancer and neurological disorders. In cancer it relates to transcription dysregulation potentially interacting with oncogenic factors. Aberrant expression or mutation of C19orf21 may disrupt normal gene regulation leading to tumorigenesis. In neurological disorders C19orf21's role in chromatin remodeling could affect gene expression patterns associated with neural function linking it to conditions such as Alzheimer's disease. In these contexts C19orf21 may interact with known proteins involved such as beta-amyloid precursor protein in Alzheimer's suggesting a wider implication in disease mechanisms.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854147801257,"sku":"ab254919","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab254919","provider":"Iright","version":"1.0","type":"link"}