{"product_id":"abcam-ab255753","title":"Abcam, ab255753, Anti-MMS21 antibody [215C] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nMouse Recombinant Monoclonal MMS21 antibody. Carrier free. Suitable for IHC-P, WB and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:215C,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab255753 is the carrier-free version of\u003cbr\u003e\nab241564\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nWant a custom formulation?\u003cbr\u003e\nThis antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMMS21 also known as NSE2 is a SUMO E3 ligase enzyme involved in sumoylation a post-translational modification process. It weighs approximately 54 kDa and plays an integral role in maintaining genome stability. MMS21 functions by transferring the SUMO protein to various substrate proteins which can alter their activity stability or localization. This protein is expressed in the nucleus where it interacts with other nuclear proteins to aid DNA repair and chromosome segregation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMMS21 participates in the structural maintenance of chromosomes (SMC) complex specifically the SMC5\/6 complex. This complex is vital for DNA repair replication and maintaining the stability of the genome. MMS21 modulates the sumoylation status of other proteins in these processes thereby influencing cell cycle progression and genomic integrity. Disruption in MMS21 activity can lead to defective chromosome maintenance highlighting its importance in cellular processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nMMS21 plays a significant role in the DNA damage response and homologous recombination repair pathways. In the DNA damage response pathway MMS21 stabilizes replication forks and mediates the repair of DNA double-strand breaks. It interacts with proteins such as RAD51 an essential protein for homologous recombination facilitating the repair of DNA. In these pathways MMS21 ensures the accuracy and effectiveness of DNA repair mechanisms preventing genomic instability.\u003cbr\u003e\nMMS21 is associated with cancer and genetic syndromes such as Fanconi anemia. The function of MMS21 in repairing DNA and maintaining genome integrity makes its dysregulation a factor in cancer development. Mutations or deficiencies in MMS21 can lead to faulty DNA repair mechanisms like those seen in Fanconi anemia a condition linked to bone marrow failure and cancer susceptibility. MMS21's interaction with other DNA repair proteins including RAD51 highlights its role in safeguarding against genomic instability seen in these diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848569278633,"sku":"ab255753","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab255753","provider":"Iright","version":"1.0","type":"link"}