{"product_id":"abcam-ab255791","title":"Abcam, ab255791, Anti-HCN1 antibody [7C3] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRat Recombinant Monoclonal HCN1 antibody. Carrier free. Suitable for WB, IHC-P and reacts with Mouse, Rat, Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rat,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:7C3,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab255791 is the carrier-free version of\u003cbr\u003e\nab252835\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nWant a custom formulation?\u003cbr\u003e\nThis antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe HCN1 protein also known as hyperpolarization-activated cyclic nucleotide-gated channel 1 or HCN1 receptor is an important component in cellular electrical activity. It has a molecular mass of approximately 91 kDa. HCN1 channels are highly expressed in the heart and nervous system particularly in regions like the cortex and hippocampus. Their principal role is serving as pacemaker channels that regulate rhythmic activity in both neurons and cardiac cells.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nHCN1 channels contribute to the generation and modulation of electrical impulses. They belong to a family of ion channels activated by membrane hyperpolarization and modulated by cyclic nucleotides. These channels are part of a larger molecular complex that includes other HCN family members such as HCN2 and HCN4 which together generate coordinated ionic currents essential for maintaining the rhythmic activity.\u003cbr\u003e\nPathways\u003cbr\u003e\nHCN1 channels significantly affect the pacing of cardiac and neuronal circuits. Within the cardiac tissue they partake in regulating heart rate through the If current or pacemaker current together with related proteins like HCN4. In the central nervous system their role extends to neuronal excitability and synaptic transmission interacting with signaling pathways that involve other ion channels and second messengers contributing to complex neuronal network activities.\u003cbr\u003e\nAlterations in HCN1 function or expression levels can lead to various conditions. In the heart dysregulation of HCN1 is associated with arrhythmias potentially involving interactions with proteins like the HCN4 channel. In the nervous system abnormal HCN1 activity has been linked to epilepsy with potential involvement of other ion channel dysfunctions. Understanding these associations provides insight into treatment strategies targeting these specific ion channel pathways.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854648987817,"sku":"ab255791","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab255791","provider":"Iright","version":"1.0","type":"link"}