{"product_id":"abcam-ab255945","title":"Abcam, ab255945, Anti-Kindlin 2 antibody [3A3.5] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nMouse Recombinant Monoclonal Kindlin 2 antibody. Carrier free. Suitable for IHC-P and reacts with Rat, Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:3A3.5,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nLight chain type:kappa,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Rat, Human,\u003cbr\u003e\nApplications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab255945 is the carrier-free version of\u003cbr\u003e\nab254535\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nWant a custom formulation?\u003cbr\u003e\nThis antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nKindlin-2 also known as FERMT2 is a mechanistic component involved in cellular adhesion processes. This protein has a molecular weight of approximately 75 kDa. Kindlin-2 is found in various tissues with high expression in epithelial cells and muscle tissues. It works together with integrins to maintain cell adhesion to the extracellular matrix performing an important role in cell communication with its surroundings.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nKindlin-2 contributes to integrin activation and cytoskeletal organization by forming part of a larger complex. This complex stabilizes integrin-talin interactions enhancing the affinity of integrins for their ligands. This function of Kindlin-2 aids in dynamically regulating cell shape migration and mechanical signaling. Its role is significant for normal cellular function and homeostasis because it helps cells to attach and detach when necessary which is important for cell movement and tissue repair.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe action of Kindlin-2 integrates with key signaling pathways like the Wnt and PI3K\/AKT pathways. In these pathways Kindlin-2 assists in transmitting signals necessary for cellular proliferation and survival. It interacts with other proteins such as talin and integrin β subunits forming a bridge between the cytoskeleton and external signals. This interaction allows cells to adapt to changes in their environment by modulating cell adhesion and migration.\u003cbr\u003e\nKindlin-2's function relates to conditions such as cancer and fibrosis. In cancer Kindlin-2 aids tumor cell migration and metastasis linking it to the pathological spread of cancerous cells. In fibrosis Kindlin-2 influences the excessive deposition of extracellular matrix components contributing to tissue scarring. The protein also interacts with fibronectin and collagens in these contexts showing its involvement in extracellular matrix remodeling and pathological tissue changes.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854640238761,"sku":"ab255945","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab255945","provider":"Iright","version":"1.0","type":"link"}