{"product_id":"abcam-ab256429","title":"Abcam, ab256429, Recombinant Rubella Virus spike glycoprotein E1 protein (Fc Chimera)","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRecombinant Rubella Virus spike glycoprotein E1 protein (Fc Chimera) is a Rubella virus strain Therien Fragment protein, in the 583 to 1025 aa range, expressed in HEK 293 cells, with \u0026gt;95%, suitable for SDS-PAGE, FuncS.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;95% SDS-PAGE,\u003cbr\u003e\nExpression system:HEK 293 cells,\u003cbr\u003e\nTags:Fc tag C-Terminus,\u003cbr\u003e\nApplications:FuncS, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:P07566,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Rubella virus strain Therien,\u003cbr\u003e\nStorage buffer:pH: 7 - 8Constituents: PBS, 0.1% 3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe Rubella virus E1 also known as the envelope glycoprotein E1 performs a critical role in the rubella virus life cycle. This protein with an approximate molecular mass of 58 kDa facilitates viral entry into host cells. It expresses on the surface of the rubella virus and enables fusion between the viral envelope and host cell membranes. Through interaction with host cell receptors E1 triggers endocytosis which allows the viral genome to enter the cytoplasm of the host cell initiating infection.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe E1 protein contributes to the formation of the rubella virus envelope complex working in tandem with another glycoprotein called E2. This complex is essential for virion assembly and maturation. The interaction between E1 and E2 is necessary for maintaining structural integrity and for ensuring the infectivity of the rubella virus. The envelope complex also plays a role in the immune evasion strategies of the virus helping it to avoid host immune surveillance.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe E1 protein's role in viral entry places it within the endocytic and membrane fusion pathways. These processes are important for host-pathogen interactions and involve coordination with cellular proteins like clathrin and dynamin. Additionally E1 works in conjunction with proteins involved in the cellular response to virus infection including interferon-induced antiviral effectors. Its interaction with these pathways highlights its importance in ensuring successful establishment and spread of infection within host tissues.\u003cbr\u003e\nThe Rubella virus E1 protein is closely associated with congenital rubella syndrome (CRS) and rubella infection itself. CRS results from maternal infection with rubella virus during pregnancy leading to severe developmental abnormalities in the fetus. E1 facilitates viral replication within the host contributing to the pathogenicity of the virus. The interaction between E1 and host cell proteins disrupts normal cellular functions which can exacerbate disease progression and lead to complications.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843914584233,"sku":"ab256429","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab256429","provider":"Iright","version":"1.0","type":"link"}