{"product_id":"abcam-ab259847","title":"Abcam, ab259847, Anti-CASZ1 antibody [EPR23824-4]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal CASZ1 antibody. Suitable for WB, IHC-Fr, IHC-P and reacts with Mouse, Rat samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR23824-4,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Rat, Mouse,\u003cbr\u003e\nApplications:IHC-Fr, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:Rat unsuitable for WB application\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCASZ1 also known as Castor zinc finger 1 is a transcription factor with a molecular mass around 131 kDa. It contains zinc finger motifs which allow it to bind DNA and regulate gene expression. This protein is ubiquitously expressed prominently found during development in tissues like the heart brain and vascular systems. CASZ1 plays an important role in cellular processes through its regulatory actions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis transcription factor influences cardiovascular development and neural differentiation. It is part of no known complex but interacts with other proteins for its function. CASZ1 regulates gene networks that are necessary for proper cell cycle progression and differentiation. Its presence ensures cells develop with the right timing and destinations especially in tissues demanding precise regulation.\u003cbr\u003e\nPathways\u003cbr\u003e\nCASZ1 integrates into significant developmental pathways. It participates in the Notch signaling pathway important for vascular development and heart formation. Through these pathways CASZ1 interacts with other proteins such as Notch receptors and Delta ligands. This linkage helps synchronize gene expression for tissue-specific development.\u003cbr\u003e\nCASZ1 links to congenital heart disease and neuroblastoma. Mutations or deregulation in CASZ1 expression have been associated with improper heart formation in congenital defects. In neuroblastoma its dysregulation alters cellular differentiation. CASZ1 interacts with proteins like MYCN in neuroblastoma relating to the malignancy's progression. Understanding CASZ1's roles could reveal therapeutic targets for these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850296905897,"sku":"ab259847","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab259847","provider":"Iright","version":"1.0","type":"link"}