{"product_id":"abcam-ab259849","title":"Abcam, ab259849, Anti-Cbx8 antibody [EPR23800-14]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal CBX8 antibody. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 2 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR23800-14,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCbx8 also known as Chromobox protein homolog 8 is part of the Polycomb group proteins with a molecular mass of approximately 50 kDa. Cbx8 functions as a transcriptional regulator by binding to histones and repressive chromatin states. It has a broad expression including in embryonic stem cells and various adult tissues. Its involvement extends to chromatin modification and impacts gene expression regulation making it significant in controlling cellular identity and differentiation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCbx8 contributes to the regulation of gene silencing within the Polycomb Repressive Complex 1 (PRC1). It plays an important role in maintaining cellular memory by ensuring heritable transcriptional repression of target genes. Cbx8's involvement in histone modification particularly histone H3 lysine 27 trimethylation (H3K27me3) is a part of its mechanism to regulate gene expression. This regulation affects key developmental processes and signals cellular differentiation pathways critical for tissue development and maintenance.\u003cbr\u003e\nPathways\u003cbr\u003e\nCbx8 engages in the Polycomb pathway where it interacts with other PRC1 proteins playing a role in chromatin compaction and silencing of developmental genes. It associates with pathways involved in cell cycle regulation and differentiation linking to essential proteins like RING1 and BMI1. These interactions enable Cbx8 to influence the transcriptional repression necessary for proper execution of developmental programs and cellular response to external signals.\u003cbr\u003e\nCbx8 has affiliations with cancer and developmental disorders due to its role in gene silencing. Abnormal Cbx8 activity may lead to disruptions in normal cell cycle controls contributing to oncogenesis with other PRC1 members like BMI1. It also connects to certain developmental syndromes where polycomb dysfunction impacts normal tissue development indicating its broader significance in maintaining cellular homeostasis and genomic stability.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850312077481,"sku":"ab259849","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab259849","provider":"Iright","version":"1.0","type":"link"}