{"product_id":"abcam-ab262917","title":"Abcam, ab262917, Anti-RBM7 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal RBM7 antibody. Suitable for IHC-P, ICC\/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human RBM7 aa 50-200.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human RBM7 aa 50-200. The exact immunogen used to generate this antibody is proprietary information.Q9Y580\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nRNA-binding protein 7 (RBM7) also known as RNA-binding motif protein 7 functions mechanically by binding to RNA. It plays a role in RNA processing and degradation. The protein has a molecular mass of approximately 30 kDa and is part of the cell's machinery that manages RNA. RBM7 is expressed in various tissues across the human body indicating a broad role in cellular functions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nRBM7 interacts with several molecular components to participate in the nuclear exosome complex. This complex is important for RNA processing and degradation ensuring proper RNA maturation and stability within cells. RBM7 influences the processing of non-coding RNAs and the turnover of messenger RNA (mRNA) impacting gene expression levels. Its interaction with other RNA-binding proteins and exosomal subunits emphasizes its role in RNA-related processes within cells.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe involvement of RBM7 extends to RNA surveillance and degradation pathways notably the exosome complex pathway. It maintains RNA quality control and stability. RBM7 works in conjunction with other exosomal proteins like EXOSC10 ensuring effective RNA decay. RBM7 indirectly influences gene expression regulation through these pathways signifying its contribution to cellular homeostasis and response to aberrant RNA.\u003cbr\u003e\nAlterations in RBM7 expression or function have been linked to neurodegenerative diseases and cancer. Its role in RNA processing may impact neuronal survival and the development of neurological conditions. RBM7's malfunction can lead to improper RNA turnover contributing to disease progression. In cancer RBM7's connection with the tumor suppressor protein TP53 highlights its involvement in the regulation of cell growth and apoptosis illustrating the protein's importance in maintaining cellular health.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854224576681,"sku":"ab262917","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab262917","provider":"Iright","version":"1.0","type":"link"}